KPV — The Anti-Inflammatory Tripeptide
KPV is small but mighty — just three amino acids (Lys-Pro-Val) clipped from the tail of α-MSH, one of the body’s own calming signals. Stripped down to its anti-inflammatory core, KPV is studied wherever inflammation and the gut lining meet, which is why it’s a favorite in “gut-repair” research. Every batch is independently third-party tested for purity and ships with its own certificate of analysis.
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- ✓ Third-party COA included
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Why source KPV from Aeternum Life
Every KPV batch is verified by an independent laboratory.
HPLC-tested identity and purity on every KPV lot.
Sourced and handled to strict, defined specifications.
Discreet, tracked delivery.
What is KPV?
KPV is a tripeptide — Lys-Pro-Val — the active tail of α-MSH (alpha-melanocyte-stimulating hormone), one of the body’s natural signals for calming inflammation. By using just this three-amino-acid piece, research focuses on the anti-inflammatory action without α-MSH’s pigmentation effects.
That focus is why KPV is a staple of gut and inflammation research — studied around the intestinal lining, plus skin and wound models. It’s a frequent partner to BPC-157 in “gut-repair” stacks. Aeternum Life supplies it as ultra-high-purity research material with a batch-specific Certificate of Analysis on every order.
Structurally KPV is about as small as a bioactive peptide gets — three residues, no disulfide bridges, no folding to speak of — which is part of why it behaves so differently from the larger repair peptides. The mechanistic work describes it entering cells directly and acting from the inside on NF-κB signalling, the master switch that turns inflammatory gene expression on, rather than docking onto a receptor at the cell surface. That intracellular route is what most KPV papers set out to characterise, and it is why the tripeptide keeps reappearing in colitis, wound-healing and skin-irritation models.
Research directions
KPV is studied where inflammation and repair overlap. Here are the main directions.
The headline: KPV carries the anti-inflammatory core of α-MSH, and that’s the center of its research.
It’s a favorite in gut research — the intestinal lining and inflammatory-bowel models.
KPV is also studied around skin and wound-healing models.
By using only the tripeptide tail, it drops α-MSH’s pigmentation effects and keeps the calming signal.
It’s commonly researched alongside BPC-157 in gut-repair stacks.
For research purposes only. These materials are not drugs or dietary supplements and are not intended to diagnose, treat, cure or prevent any disease.
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How KPV is tested
- Certificate of Analysis (COA) for every KPV batch
- HPLC purity & identity
- Mass-spectrometry confirmed
- Batch-tested and fully traceable
Every KPV lot is released only after independent verification, so what you receive matches its stated identity and purity.
Handling & Storage
Guidance for handling KPV as a laboratory research material.
Store lyophilized KPV cold and protected from light, sealed and dry until use.
Handle KPV according to standard laboratory practice for research materials.
Each KPV batch ships with a batch-specific COA for identity and purity.
KPV is supplied strictly for laboratory and research use. Not for human or veterinary consumption; no administration or dosing guidance is provided.
Specifications
- Name
- KPV (Lys-Pro-Val)
- CAS
- 67727-97-3
- Sequence
- Lys-Pro-Val
- Appearance
- White lyophilized powder
- Size
- 10 mg per vial
- Purity
- ≥ 99% (HPLC, see COA)
- Storage
- Store at 2–8°C, protect from light
For research use. Not intended to diagnose, treat, cure or prevent any disease.
Frequently asked questions
How is KPV different from α-MSH itself?
KPV is only the final three residues of α-MSH. The full hormone also drives pigmentation through melanocortin receptors, while the tripeptide fragment is studied specifically because it carries the anti-inflammatory signalling without that receptor activity. That separation is the entire reason KPV exists as a research material in its own right.
What is KPV studied for?
It’s studied around inflammation and the gut lining, plus skin and wound models. We share these as research directions, not medical claims.
Why is it paired with BPC-157?
KPV (anti-inflammatory) and BPC-157 (repair) target the gut from two angles, which is why they’re so often researched together. Reconstitution and handling guides are shared in our Telegram community.
Is KPV for human use?
No. Aeternum Life supplies KPV strictly as a research-grade material for laboratory research. It is not sold for human or veterinary consumption.
Is a COA available for KPV?
Yes — every KPV batch ships with a batch-specific Certificate of Analysis covering identity and purity.
About Aeternum Life
Aeternum Life is a Japan-inspired peptide brand built on purity, transparency and rigorous testing — the same standard behind the KPV on this page. Every product is presented by its composition and backed by batch-specific documentation.
Explore the full Aeternum Life range
KPV is one of more than thirty research-grade materials we supply — each one backed by a batch-specific COA and independent testing.
- ✓ Credit card / Apple Pay accepted
- ✓ Third-party COA included
- ✓ Free worldwide shipping over $99